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标题：Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
其他标题：Body composition, but not insulin resistance, influences postprandial lipemia in patients with Turner's syndrome
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作者：Siqueira, Rodrigo de Azeredo ; Carlos, Aluana Santana ; d'Avila, Joana Costa 等
期刊名称：Archives of Endocrinology and Metabolism
印刷版ISSN：2359-3997
出版年度：2020
卷号：64
期号：6
页码：758-763
DOI：10.20945/2359-3997000000287
出版社：Archives of Endocrinology and Metabolism
摘要：Objective: The aim of the present study was to examine the influence of body composition and insulin resistance on the magnitude of postprandial lipemia in patients with Turner's syndrome receiving oral versus transdermal estrogen replacement. Subjects and methods: Twenty-five patients with Turner's syndrome receiving oral or transdermal estrogen replacement were evaluated for body mass index, waist-to-hip and waist-to-height ratios, fasting glycemia, insulin, body composition (dual-energy X-ray absorptiometry), and postprandial lipid metabolism. For statistical analysis, we used parametric tests to compare numeric variables between the two subgroups. Results: We observed no difference in postprandial triglyceride levels between patients receiving oral versus transdermal hormone replacement therapy. The postprandial triglycerides increment correlated positively with the percentage of total fat mass (p=0.02) and android fat mass (p=0.02) in the transdermal group. In the oral estrogen group, a positive correlation was observed between the increment in postprandial triglycerides and waist-to-hip (p=0.15) and waist-to-height (p=0.009) ratios. No association was observed between the estrogen replacement route and insulin resistance evaluated by the homeostatic model assessment–insulin resistance (HOMA-IR) index (p=0.19 and p=0.65 for the oral and transdermal groups, respectively). Conclusion: We concluded that body composition and anthropometric characteristics possibly affect the extent of postprandial lipemia independently from the route of estrogen replacement.
关键词：Hyperlipidemia; hormone replacement therapy; Turner's syndrome; estrogen replacement therapy; insulin resistance.
其他关键词：Hyperlipidemia;hormone replacement therapy;Turner's syndrome;estrogen replacement therapy;insulin resistance