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标题：Metabolomics as a potential tool for the diagnosis of growth hormone deficiency (GHD): a review
其他标题：Metabolomics as a potential tool for the diagnosis of growth hormone deficiency (GHD): a review
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作者：San-Martin, Breno Sena De ; Ferreira, Vinícius Guimarães ; Bitencourt, Mariana Rechia 等
期刊名称：Archives of Endocrinology and Metabolism
印刷版ISSN：2359-3997
出版年度：2020
卷号：64
期号：6
页码：654-663
DOI：10.20945/2359-3997000000300
出版社：Archives of Endocrinology and Metabolism
摘要：Metabolomics uses several analytical tools to identify the chemical diversity of metabolites present in organisms. These metabolites are low molecular weight molecules (<1500 Da) classified as a final or intermediary product of metabolic processes. The application of this omics technology has become prominent in inferring physiological conditions through reporting on the phenotypic state; therefore, the introduction of metabolomics into clinical studies has been growing in recent years due to its efficiency in discriminating pathophysiological states. Regarding endocrine diseases, there is a great interest in verifying comprehensive and individualized physiological scenarios, in particular for growth hormone deficiency (GHD). The current GHD diagnostic tests are laborious and invasive and there is no exam with ideal reproducibility and sensitivity for diagnosis neither standard GH cut-off point. Therefore, this review was focussed on articles that applied metabolomics in the search for new biomarkers for GHD. The present work shows that the applications of metabolomics in GHD are still limited, since the little complementarily of analytical techniques, a low number of samples, GHD combined to other deficiencies, and idiopathic diagnosis shows a lack of progress. The results of the research are relevant and similar; however, their results do not provide an application for clinical practice due to the lack of multidisciplinary actions that would be needed to mediate the translation of the knowledge produced in the laboratory, if transferred to the medical setting.
关键词：Metabolomics; GHD; metabolites; pathophysiology; translational.
其他关键词：Metabolomics;GHD;metabolites;pathophysiology;translational