文章基本信息

标题：Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation
本地全文：下载
作者：Qianwen Ma ; Genlin Mo ; Yong Tan 等
期刊名称：African Health Sciences
印刷版ISSN：1680-6905
电子版ISSN：1729-0503
出版年度：2020
卷号：20
期号：4
页码：1887-1894
DOI：10.4314/ahs.v20i4.46
出版社：Makerere University Medical School（Uganda)
摘要：Background: Circadian clocks are self-sustaining oscillators that coordinate behavior and physiology over a 24 hour peri- od, achieving time-dependent homeostasis with the external environment. The molecular clocks driving circadian rhythmic changes are based on intertwined transcriptional/translational feedback loops that combine with a range of environmental and metabolic stimuli to generate daily internal programing. Understanding how biological rhythms are generated through- out the body and the reasons for their dysregulation can provide avenues for temporally directed therapeutics. Summary: In recent years, microRNAs have been shown to play important roles in the regulation of the circadian clock, particularly in Drosophila, but also in some small animal and human studies. This review will summarize our current un- derstanding of the role of miRNAs during clock regulation, with a particular focus on the control of clock regulated gene expression.
关键词：: MicroRNAs; biological clock; circadian rhythm;