文章基本信息

标题：Association of ERCC gene polymorphism with osteosarcoma risk
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作者：Guanliang Wang ; Jianping Li ; Xiling Xu 等
期刊名称：African Health Sciences
印刷版ISSN：1680-6905
电子版ISSN：1729-0503
出版年度：2020
卷号：20
期号：4
页码：1840-1848
DOI：10.4314/ahs.v20i4.39
出版社：Makerere University Medical School（Uganda)
摘要：Background: The relationship between ERCC gene polymorphism and osteosarcoma risk / overall survival of osteosarco- ma is still conflicting, and this meta-analysis was performed to assess these associations. Material and methods: The association studies were identified from PubMed, and eligible reports were included and cal- culated using meta-analysis method. Results: Four studies were included for the association of ERCC gene polymorphism with osteosarcoma risk, and nine studies were recruited into this meta-analysis for the relationship between ERCC gene polymorphism and overall survival of osteosarcoma. The meta-analysis indicated that ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (A>G) gene polymorphism, ERCC2 rs13181 (Lys751Gln) gene pol- ymorphism were not associated with osteosarcoma risk. ERCC1 rs2298881 (C>A) gene polymorphism, ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (Asp312Asn) gene polymorphism were not associated with overall survival of osteosarcoma. Interestingly, ERCC2 rs13181 A allele and GG genotype were associated with overall survival of osteosarcoma, but AA genotype not (A allele: OR = 0.78, 95% CI: 0.65- 0.93, P = 0.007; GG genotype: OR = 1.32, 95% CI: 1.05-1.65, P = 0.02; AA genotype: OR = 0.69, 95% CI: 0.45-1.04, P = 0.08). Conclusion: ERCC2 rs13181 A allele and GG genotype were associated with overall survival of osteosarcoma.
关键词：Osteosarcoma; overall survival of osteosarcoma; ERCC; gene polymorphism; meta-analysis;