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  • 标题:Developmental outcomes of HIV-exposed infants in a low-income South African context
  • 本地全文:下载
  • 作者:Carmen Cornelia de Beer ; Esedra Krüger ; Jeannie van der Linde
  • 期刊名称:African Health Sciences
  • 印刷版ISSN:1680-6905
  • 电子版ISSN:1729-0503
  • 出版年度:2020
  • 卷号:20
  • 期号:4
  • 页码:1734-1741
  • DOI:10.4314/ahs.v20i4.25
  • 出版社:Makerere University Medical School(Uganda)
  • 摘要:Background: Effective HIV transmission prevention strategies have led to a growing population of vulnerable HIV- and antiretroviral-exposed infants in sub-Saharan Africa, however uncertainty exists regarding their development. Objective: To determine the developmental outcomes of HIV-exposed (HE) infants in a low-income South African con- text, when compared to HIV-unexposed (HU) counterparts. Methods: In this prospective cross-sectional, group comparison study, the development of 41 HE and 40 HU infants (mean age=8.4 months, SD=2.1 months) from a low-income context was assessed. Caregivers were interviewed using the Vineland Adaptive Behavior Scales, Third Edition (Vineland-3) to evaluate infants’ development. Results: Most HE participants had age-appropriate overall development (90.2%;n=37). Some HE participants, however, presented with delays in domains of communication (9.8%;n=4), daily living skills (2.4%;n=1), socialisation (19.5%;n=8), and motor development (7.3%;n=3). HU participants also demonstrated some domain-specific delays, thus delays were present in both groups. No statistically significant between-group differences regarding development were found. Conclusion: Findings were reassuring and suggested that HE and HU participants had similar development. Developmen- tal differences may, however, only emerge with age, therefore large-scale longitudinal research is recommended. It is suggest- ed that the entire sample was vulnerable, highlighting the importance of developmental surveillance in low-income contexts, irrespective of HIV and antiretroviral exposure status.
  • 关键词:Developmental outcomes; HIV-exposed infants; low-income context;
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