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  • 标题:The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review
  • 本地全文:下载
  • 作者:Dominika Jakubczyk ; Katarzyna Leszczyńska ; Sabina Górska
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2020
  • 卷号:12
  • 期号:7
  • 页码:1973-1997
  • DOI:10.3390/nu12071973
  • 出版社:MDPI Publishing
  • 摘要:Inflammatory bowel disease (IBD), which affects millions of people worldwide, includes two separate diseases: Crohn’s disease (CD) and ulcerative colitis (UC). Although the background (chronic inflammatory state) and some of the symptoms of CD and UC are similar, both diseases differ from each other. It is becoming clear that a combination of many factors, in particular genetic background, host immune response and microbial reduced diversity status are associated with IBD. One potential strategy to prevent/treat IBD is gut modulation by probiotics. Over the last twenty years, many publications have focused on the role of probiotics in the course of IBD. The review discusses the utility of different strains of probiotics, especially Bifidobacterium spp., in all factors potentially involved in the etiology of IBD. The probiotic modulatory properties among different study models (cell lines, animal models of colitis, clinical study) are discussed and probiotic usefulness is assessed in relation to the treatment, prevention, and remission of diseases.
  • 关键词:probiotic; inflammatory bowel disease; Bifidobacterium ; Crohn’s disease; ulcerative colitis; treatment; anti-inflammatory probiotic ; inflammatory bowel disease ; Bifidobacterium ; Crohn’s disease ; ulcerative colitis ; treatment ; anti-inflammatory
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