文章基本信息

标题：Vitamin K2 Needs an RDI Separate from Vitamin K1
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作者：Asim Cengiz Akbulut ; Angelina Pavlic ; Ploingarm Petsophonsakul 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：6
页码：1852-1864
DOI：10.3390/nu12061852
出版社：MDPI Publishing
摘要：Vitamin K and its essential role in coagulation (vitamin K [Koagulation]) have been well established and accepted the world over. Many countries have a Recommended Daily Intake (RDI) for vitamin K based on early research, and its necessary role in the activation of vitamin K-dependent coagulation proteins is known. In the past few decades, the role of vitamin K-dependent proteins in processes beyond coagulation has been discovered. Various isoforms of vitamin K have been identified, and vitamin K2 specifically has been highlighted for its long half-life and extrahepatic activity, whereas the dietary form vitamin K1 has a shorter half-life. In this review, we highlight the specific activity of vitamin K2 based upon proposed frameworks necessary for a bioactive substance to be recommended for an RDI. Vitamin K2 meets all these criteria and should be considered for a specific dietary recommendation intake.
关键词：vitamin K; vitamin K1; vitamin K2; RDI; menaquinone; vitamin K-dependent proteins vitamin K ; vitamin K1 ; vitamin K2 ; RDI ; menaquinone ; vitamin K-dependent proteins