文章基本信息

标题：Dietary n-6/n-3 Ratio Influences Brain Fatty Acid Composition in Adult Rats
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作者：Thomas Horman ; Maria F. Fernandes ; Maria C. Tache 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：6
页码：1847-1856
DOI：10.3390/nu12061847
出版社：MDPI Publishing
摘要：There is mounting evidence that diets supplemented with polyunsaturated fatty acids (PUFA) can impact brain biology and functions. This study investigated whether moderately high-fat diets differing in n-6/n-3 fatty acid ratio could impact fatty acid composition in regions of the brain linked to various psychopathologies. Adult male Sprague Dawley rats consumed isocaloric diets (35% kcal from fat) containing different ratios of linoleic acid (n-6) and alpha-linolenic acid (n-3) for 2 months. It was found that the profiles of PUFA in the prefrontal cortex, hippocampus, and hypothalamus reflected the fatty acid composition of the diet. In addition, region-specific changes in saturated fatty acids and monounsaturated fatty acids were detected in the hypothalamus, but not in the hippocampus or prefrontal cortex. This study in adult rats demonstrates that fatty acid remodeling in the brain by diet can occur within months and provides additional evidence for the suggestion that diet could impact mental health.
关键词：polyunsaturated fatty acids; linoleic acid; α-linolenic acid; diet; rat; brain polyunsaturated fatty acids ; linoleic acid ; α-linolenic acid ; diet ; rat ; brain