文章基本信息

标题：Bifidobacterium longum Subspecies infantis (B. infantis) in Pediatric Nutrition: Current State of Knowledge
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作者：Maciej Chichlowski ; Neil Shah ; Jennifer L. Wampler 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：6
页码：1581-1598
DOI：10.3390/nu12061581
出版社：MDPI Publishing
摘要：Since originally isolated in 1899, the genus Bifidobacterium has been demonstrated to predominate in the gut microbiota of breastfed infants and to benefit the host by accelerating maturation of the immune response, balancing the immune system to suppress inflammation, improving intestinal barrier function, and increasing acetate production. In particular, Bifidobacterium longum subspecies infantis (B. infantis) is well adapted to the infant gut and has co-evolved with the mother-infant dyad and gut microbiome, in part due to its ability to consume complex carbohydrates found in human milk. B. infantis and its human host have a symbiotic relationship that protects the preterm or term neonate and nourishes a healthy gut microbiota prior to weaning. To provide benefits associated with B. infantis to all infants, a number of commercialized strains have been developed over the past decades. As new ingredients become available, safety and suitability must be assessed in preclinical and clinical studies. Consideration of the full clinical evidence for B. infantis use in pediatric nutrition is critical to better understand its potential impacts on infant health and development. Herein we summarize the recent clinical studies utilizing select strains of commercialized B. infantis.
关键词：Bifidobacterium longum subspecies infantis ; B; infantis ; probiotics; pediatric nutrition; human milk oligosaccharides; inflammation; gut health; microbiome; short chain fatty acids; acetate Bifidobacterium longum subspecies infantis ; B; infantis ; probiotics ; pediatric nutrition ; human milk oligosaccharides ; inflammation ; gut health ; microbiome ; short chain fatty acids ; acetate