文章基本信息

标题：The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment
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作者：Magdalena Nowaczewska ; Michał Wiciński ; Stanisław Osiński 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：1
页码：243-259
DOI：10.3390/nu12010243
出版社：MDPI Publishing
摘要：Some studies have suggested a link between vitamin D and headache; however, the underlying physiological mechanisms are unclear. We aimed to summarize the available evidence on the relationship between vitamin D and the various subtypes of primary headaches, including migraines and tension-type headaches. All articles concerning the association between primary headache and vitamin D published up to October 2019 were retrieved by searching clinical databases, including: EMBASE, MEDLINE, PubMed, Google scholar, and the Cochrane library. All types of studies (i.e., observational, cross-sectional, case-control, and clinical trials) were included. We identified 22 studies investigating serum vitamin D levels in association with headaches. Eight studies also evaluated the effect of vitamin D supplementation on the various headache parameters. Among them, 18 studies showed a link between serum vitamin D levels and headaches, with the strongest connection reported between serum vitamin D levels and migraine. Overall, there is not enough evidence to recommend vitamin D supplementation to all headache patients, but the current literature indicates that it may be beneficial in some patients suffering headaches, mainly migraineurs, to reduce the frequency of headaches, especially in those with vitamin D deficiency.
关键词：cholecalciferol; headache; migraine; tension-type headache; cluster headache; pain; vitamin D; 25-hydroxy-vitamin D cholecalciferol ; headache ; migraine ; tension-type headache ; cluster headache ; pain ; vitamin D ; 25-hydroxy-vitamin D