文章基本信息

标题：Potential Mechanisms of Probiotics Action in the Prevention and Treatment of Colorectal Cancer
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作者：Marta Molska ; Julita Reguła
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：10
页码：2453-2469
DOI：10.3390/nu11102453
出版社：MDPI Publishing
摘要：Colorectal cancer is one of the most common and most diagnosed cancers in the world. There are many predisposing factors, for example, genetic predisposition, smoking, or a diet rich in red, processed meat and poor in vegetables and fruits. Probiotics may be helpful in the prevention of cancer and may provide support during treatment. The main aim of this study is to characterize the potential mechanisms of action of probiotics, in particular the prevention and treatment of colorectal cancer. Probiotics’ potential mechanisms of action are, for example, modification of intestinal microbiota, improvement of colonic physicochemical conditions, production of anticancerogenic and antioxidant metabolites against carcinogenesis, a decrease in intestinal inflammation, and the production of harmful enzymes. The prevention of colorectal cancer is associated with favorable quantitative and qualitative changes in the intestinal microbiota, as well as changes in metabolic activity and in the physicochemical conditions of the intestine. In addition, it is worth noting that the effect depends on the bacterial strain, as well as on the dose administered.
关键词：lactic acid bacteria; mechanism of probiotic action; anticancerogenic action of probiotics; therapeutic dose; therapy and protective effects lactic acid bacteria ; mechanism of probiotic action ; anticancerogenic action of probiotics ; therapeutic dose ; therapy and protective effects