文章基本信息

标题：The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial
本地全文：下载
作者：Yeek Tat Ng ; Sonia Chew Wen Phang ; Gerald Chen Jie Tan 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：5
页码：1522-1536
DOI：10.3390/nu12051522
出版社：MDPI Publishing
摘要：Chronic hyperglycemia increases oxidative stress, activates inflammatory pathways and reduces nerve growth factor (NGF) among diabetic patients, which contribute to development of diabetic peripheral neuropathy (DPN). Tocotrienol-Rich Vitamin E (Tocovid) possesses potent antioxidant and anti-inflammatory properties which are postulated to target these pathogeneses in order to ameliorate DPN. This study aims to evaluate the effects of Tocovid on nerve conduction parameters and serum biomarkers among diabetic patients. This multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial was conducted on 80 eligible participants. The intervention group (n = 39) was randomly allocated to receive 200 mg of Tocovid twice a day, and the control group (n = 41) received placebo twice a day. At the end of eight weeks, the nerve conduction parameters, as assessed by nerve conduction study, as well as serum biomarkers (NGF, malondialdehyde, vascular cell adhesion molecule 1, tumor necrosis factor receptor 1 and thromboxane B2) were compared between the two groups. Compared to placebo, Tocovid significantly improves the nerve conduction velocities of all nerves ( 1.25 m/s, interquartile range [IQR] 3.35, p < 0.001, median nerve; 1.60 m/s, IQR 1.80, p < 0.001, sural nerve; 0.75 m/s, IQR 2.25, p < 0.001, tibial nerve). Meanwhile, the levels of serum NGF were significantly higher in the Tocovid group as compared to placebo at eight weeks post-intervention. Participants receiving Tocovid illustrated highly significant improvement in terms of nerve conduction velocities for all nerves tested after eight weeks of supplementation. In addition, Tocovid supplementation elevated the levels of serum NGF, in which its increase is postulated to reflect enhanced neuronal functions. This novel finding suggests that Tocovid could be a disease-modifying agent targeting serum NGF to improve nerve conduction velocities.
关键词：type 2 diabetes mellitus; diabetic peripheral neuropathy; tocotrienol; vitamin E; nerve conduction velocity; nerve conduction study; nerve growth factor (NGF); malondialdehyde (MDA); vascular cell adhesion molecule 1 (VCAM-1); tumor necrosis factor receptor 1 (TNFR-1) type 2 diabetes mellitus ; diabetic peripheral neuropathy ; tocotrienol ; vitamin E ; nerve conduction velocity ; nerve conduction study ; nerve growth factor (NGF) ; malondialdehyde (MDA) ; vascular cell adhesion molecule 1 (VCAM-1) ; tumor necrosis factor receptor 1 (TNFR-1)