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标题：Vitamin D Deficiency and Oral Health: A Comprehensive Review
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作者：João Botelho ; Vanessa Machado ; Luís Proença 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：5
页码：1471-1486
DOI：10.3390/nu12051471
出版社：MDPI Publishing
摘要：Vitamin D (VD) levels have been gaining growing attention in Oral Health. During growth and adulthood, VD deficiency (VDD) is associated with a wide variety of oral health disorders, and impaired VD synthesis may expedite some of these conditions. In children, severe VDD can induce defective tooth mineralization, resulting in dentin and enamel defects. As a consequence, these defects may increase the risk of the onset and progression of dental caries. Further, VDD has been associated with higher prevalence of periodontitis and gingival inflammation, and several recent preclinical and clinical studies have unveiled potential pathways through which Vitamin D may interact with the periodontium. VDD correction through supplementation may contribute to a successful treatment of periodontitis; however, alveolar bone regeneration procedures performed in baseline VDD patients seem more prone to failure. Vitamin D may also be linked with some oral pathology entities such as certain oral cancers and events of osteonecrosis of the jaw. This review aims to provide comprehensive evidence of how VD levels should be considered to promote good oral health, and to summarize how VDD may hamper oral development and its role in certain oral conditions.
关键词：vitamins; vitamin D deficiency; oral health; periodontal health; periodontal disease; periodontitis; caries; orthodontics; oral cancer vitamins ; vitamin D deficiency ; oral health ; periodontal health ; periodontal disease ; periodontitis ; caries ; orthodontics ; oral cancer