文章基本信息

标题：Trimethylamine N-Oxide in Relation to Cardiometabolic Health—Cause or Effect?
本地全文：下载
作者：Christopher Papandreou ; Margret Moré ; Aouatef Bellamine 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：5
页码：1330-1365
DOI：10.3390/nu12051330
出版社：MDPI Publishing
摘要：Trimethylamine-N-oxide (TMAO) is generated in a microbial-mammalian co-metabolic pathway mainly from the digestion of meat-containing food and dietary quaternary amines such as phosphatidylcholine, choline, betaine, or L-carnitine. Fish intake provides a direct significant source of TMAO. Human observational studies previously reported a positive relationship between plasma TMAO concentrations and cardiometabolic diseases. Discrepancies and inconsistencies of recent investigations and previous studies questioned the role of TMAO in these diseases. Several animal studies reported neutral or even beneficial effects of TMAO or its precursors in cardiovascular disease model systems, supporting the clinically proven beneficial effects of its precursor, L-carnitine, or a sea-food rich diet (naturally containing TMAO) on cardiometabolic health. In this review, we summarize recent preclinical and epidemiological evidence on the effects of TMAO, in order to shed some light on the role of TMAO in cardiometabolic diseases, particularly as related to the microbiome.
关键词：trimethylamine N-oxide (TMAO); cardiovascular disease; type 2 diabetes; atherosclerosis; cardiometabolic health; cause‒effect relationship trimethylamine N-oxide (TMAO) ; cardiovascular disease ; type 2 diabetes ; atherosclerosis ; cardiometabolic health ; cause‒effect relationship