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标题：Vitamin D’s Effect on Immune Function
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作者：Pieter-Jan Martens ; Conny Gysemans ; Annemieke Verstuyf 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：5
页码：1248-1269
DOI：10.3390/nu12051248
出版社：MDPI Publishing
摘要：Ever since its discovery by Windhaus, the importance of the active metabolite of vitamin D (1,25-dihydroxyvitamin D3; 1,25-(OH)2D3) has been ever expanding. In this review, the attention is shifted towards the importance of the extra-skeletal effects of vitamin D, with special emphasis on the immune system. The first hint of the significant role of vitamin D on the immune system was made by the discovery of the presence of the vitamin D receptor on almost all cells of the immune system. In vitro, the overwhelming effect of supra-physiological doses of vitamin D on the individual components of the immune system is very clear. Despite these promising pre-clinical results, the translation of the in vitro observations to solid clinical effects has mostly failed. Nevertheless, the evidence of a link between vitamin D deficiency and adverse outcomes is overwhelming and clearly points towards avoidance of vitamin D deficiency especially in early life.
关键词：vitamin D; 1;25-(OH)2D3; immune system; autoimmune disease; infectious disease; type 1 diabetes; multiple sclerosis; rheumatoid arthritis vitamin D ; 1;25-(OH)2D3 ; immune system ; autoimmune disease ; infectious disease ; type 1 diabetes ; multiple sclerosis ; rheumatoid arthritis