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标题：Monoacylglycerol Form of Omega-3s Improves Its Bioavailability in Humans Compared to Other Forms
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作者：Bernard Cuenoud ; Isabelle Rochat ; Maria Laura Gosoniu 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：4
页码：1014-1034
DOI：10.3390/nu12041014
出版社：MDPI Publishing
摘要：Numerous benefits are attributed to omega-3 fatty acids (OM3) especially in cardiovascular health. However, bioavailability and clinical efficacy depend on numerous factors, including OM3 form, food matrix effects (especially the lipid content of the diet), and metabolic capacity. Here, we show in humans that a “pre-digested” OM3-sn-1(3)-monoacylglycerol lipid structure (OM3-MAG) has a significantly greater absorption at high therapeutic doses (2.9 g/day) than the most commonly OM3-ethyl ester (3.1 g/day) form (used for the treatment of hypertriglyceridemia), and a comparable profile to other pre-digested OM3 free fatty acids (OM3-FFA) structure (3.2 g/day). Nutritional supplement doses of MAG resulted in similar increases in OM3 blood level, compared to OM3 triacylglycerols (OM3-TAG) supplements in obese subjects (1.2 g/day) under low fat diet, and in children with cystic fibrosis (1.0 g/day). These results suggest that both forms of pre-digested OM3-MAG and OM3-FFA are effectively absorbed and re-incorporated effectively into triacylglycerols inside the enterocytes, before being exported into the chylomicrons lipid transport system. The pre-digested OM3-MAG might provide a more effective therapy in severe cardiovascular conditions where high doses of OM3 are required and a low-fat diet is indicated, which limited digestive lipase activity.
关键词：omega-3 sn -1(3)-monoacylglycerol; fatty acid digestion; omega 3; lipid absorption; cystic fibrosis; obesity; hypertriglyceridemia omega-3 sn -1(3)-monoacylglycerol ; fatty acid digestion ; omega 3 ; lipid absorption ; cystic fibrosis ; obesity ; hypertriglyceridemia