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标题：A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models
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作者：Maria Maares ; Hajo Haase
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：3
页码：762-804
DOI：10.3390/nu12030762
出版社：MDPI Publishing
摘要：Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic homeostasis of this essential trace element. This review summarizes the key aspects of human zinc homeostasis and distribution. In particular, current knowledge on human intestinal zinc absorption and the influence of diet-derived factors on bioaccessibility and bioavailability as well as intrinsic luminal and basolateral factors with an impact on zinc uptake are discussed. Their investigation is increasingly performed using in vitro cellular intestinal models, which are continually being refined and keep gaining importance for studying zinc uptake and transport via the human intestinal epithelium. The vast majority of these models is based on the human intestinal cell line Caco-2 in combination with other relevant components of the intestinal epithelium, such as mucin-secreting goblet cells and in vitro digestion models, and applying improved compositions of apical and basolateral media to mimic the in vivo situation as closely as possible. Particular emphasis is placed on summarizing previous applications as well as key results of these models, comparing their results to data obtained in humans, and discussing their advantages and limitations.
关键词：zinc; intestinal absorption; zinc homeostasis; zinc bioavailability; zinc uptake; in vitro intestinal model; Caco-2; intestinal zinc ; intestinal absorption ; zinc homeostasis ; zinc bioavailability ; zinc uptake ; in vitro intestinal model ; Caco-2 ; intestinal