文章基本信息

标题：Relationship of Wine Consumption with Alzheimer’s Disease
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作者：Marcella Reale ; Erica Costantini ; Srinivas Jagarlapoodi 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：1
页码：206-223
DOI：10.3390/nu12010206
出版社：MDPI Publishing
摘要：Background: Alzheimer’s disease (AD), the most threatening neurodegenerative disease, is characterized by the loss of memory and language function, an unbalanced perception of space, and other cognitive and physical manifestations. The pathology of AD is characterized by neuronal loss and the extensive distribution of senile plaques and neurofibrillary tangles (NFTs). The role of environment and the diet in AD is being actively studied, and nutrition is one of the main factors playing a prominent role in the prevention of neurodegenerative diseases. In this context, the relationship between dementia and wine use/abuse has received increased research interest, with varying and often conflicting results. Scope and Approach: With this review, we aimed to critically summarize the main relevant studies to clarify the relationship between wine drinking and AD, as well as how frequency and/or amount of drinking may influence the effects. Key Findings and Conclusions: Overall, based on the interpretation of various studies, no definitive results highlight if light to moderate alcohol drinking is detrimental to cognition and dementia, or if alcohol intake could reduce risk of developing AD.
关键词：alcohol consumption; Alzheimer’s disease; light to moderate wine consumption; neurodegeneration alcohol consumption ; Alzheimer’s disease ; light to moderate wine consumption ; neurodegeneration