文章基本信息

标题：The Kidney–Gut–Muscle Axis in End-Stage Renal Disease is Similarly Represented in Older Adults
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作者：Tanja Tilles-Tirkkonen ; Kirsikka Aittola ; Reija Männikkö 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：1
页码：106-113
DOI：10.3390/nu12010106
出版社：MDPI Publishing
摘要：Decreased renal function, elevated circulating levels of urea, intestinal levels of urea-degrading bacteria, and gut-derived uremic metabolites are present in end-stage renal disease (ESRD), a cohort that has reduced muscle mass and physical function, and poor muscle composition. This phenotype, defined as the kidney–gut–muscle axis, is similarly represented in older adults that do not have ESRD. The purpose of this short communication is to illuminate these findings, and to propose a strategy that can positively impact the kidney–gut–muscle axis. For example, dietary fiber is fermented by intestinal bacteria, thereby producing the short-chain fatty acids (SCFAs) acetate, propionate, and butyrate, which affect each component of the kidney–gut–muscle axis. Accordingly, a high-fiber diet may be an important approach for improving the kidney–gut–muscle axis in ESRD and in older adults that do not have ESRD.
关键词：ESRD; gut microbiome-derived uremic metabolites; aging; renal function; sarcopenia; muscle composition ESRD ; gut microbiome-derived uremic metabolites ; aging ; renal function ; sarcopenia ; muscle composition