文章基本信息

标题：Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction
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作者：Carlos González-Quilen ; Esther Rodríguez-Gallego ; Raúl Beltrán-Debón 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：1
页码：130-157
DOI：10.3390/nu12010130
出版社：MDPI Publishing
摘要：The intestinal barrier is constantly exposed to potentially harmful environmental factors, including food components and bacterial endotoxins. When intestinal barrier function and immune homeostasis are compromised (intestinal dysfunction), inflammatory conditions may develop and impact overall health. Evidence from experimental animal and cell culture studies suggests that exposure of intestinal mucosa to proanthocyanidin (PAC)-rich plant products, such as grape seeds, may contribute to maintaining the barrier function and to ameliorating the pathological inflammation present in diet-induced obesity and inflammatory bowel disease. In this review, we aim to update the current knowledge on the bioactivity of PACs in experimental models of intestinal dysfunction and in humans, and to provide insights into the underlying biochemical and molecular mechanisms.
关键词：gut; permeability; inflammation; metabolic endotoxemia; obesity; IBD; flavonoid; flavan-3-ol; condensed tannin; procyanidin gut ; permeability ; inflammation ; metabolic endotoxemia ; obesity ; IBD ; flavonoid ; flavan-3-ol ; condensed tannin ; procyanidin