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标题：Anti-Osteoporotic Effects of Combined Extract of Lycii Radicis Cortex and Achyranthes japonica in Osteoblast and Osteoclast Cells and Ovariectomized Mice
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作者：Eunkuk Park ; Jeonghyun Kim ; Subin Yeo 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：11
页码：2716-2728
DOI：10.3390/nu11112716
出版社：MDPI Publishing
摘要：Osteoporosis is characterized by low bone density and quality with high risk of bone fracture. Here, we investigated anti-osteoporotic effects of natural plants (Lycii Radicis Cortex (LRC) and Achyranthes japonica (AJ)) in osteoblast and osteoclast cells in vitro and ovariectomized mice in vivo. Combined LRC and AJ enhanced osteoblast differentiation and mineralized bone-forming osteoblasts by the up-regulation of bone metabolic markers (Alpl, Runx2 and Bglap) in the osteoblastic cell line MC3T3-E1. However, LRC and AJ inhibited osteoclast differentiation of monocytes isolated from mouse bone marrow. In vivo experiments showed that treatment of LRC AJ extract prevented OVX-induced trabecular bone loss and osteoclastogenesis in an osteoporotic animal model. These results suggest that LRC AJ extract may be a good therapeutic agent for the treatment and prevention of osteoporotic bone loss.
关键词：Lycii Radicis Cortex ; Achyranthes japonica; osteoporosis; ovariectomized mice; osteoblast; osteoclast Lycii Radicis Cortex ; Achyranthes japonica ; osteoporosis ; ovariectomized mice ; osteoblast ; osteoclast