文章基本信息

标题：Management of Cow’s Milk Allergy from an Immunological Perspective: What Are the Options?
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作者：Edward F. Knol ; Nicolette W. de Jong ; Laurien H. Ulfman 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：11
页码：2734-2741
DOI：10.3390/nu11112734
出版社：MDPI Publishing
摘要：The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow’s milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes is effective in the reduction of allergic symptoms but it cannot be envisioned as a treatment. For the treatment and prevention of IgE-mediated cow’s milk allergy, it is thought that the induction of a sustained state of immunological tolerance is needed. In this review, we will discuss various approaches aimed at achieving immunological tolerance and their success. Furthermore, we will speculate on the involved immunological mechanism.
关键词：allergy; cow’s milk; formula; therapy; immune cells; Immunoglubuline E allergy ; cow’s milk ; formula ; therapy ; immune cells ; Immunoglubuline E