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标题：Are Circulating Mg2 Levels Associated with Glucose Tolerance Profiles and Incident Type 2 Diabetes?
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作者：Rosangela Spiga ; Gaia Chiara Mannino ; Elettra Mancuso 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：10
页码：2460-2468
DOI：10.3390/nu11102460
出版社：MDPI Publishing
摘要：Magnesium (Mg2 ) is an enzyme co-factor that plays a key role in many biochemical reactions, as well as in glucose metabolism. Clinical evidences have demonstrated that depletion of serum Mg2 increases exponentially with the duration of type 2 diabetes mellitus (T2DM). Diabetes is associated with low Mg2 , and hypomagnesemia is associated with insulin resistance, inflammation, and increased risk for cardiovascular disease. In subjects at high risk of inflammation and insulin resistance, supplementation of Mg2 alone ameliorates both phenotypes, slowing the development and progression of hepatic steatosis. We analyze the relationship between serum Mg2 levels and the onset of T2DM in a large cohort of well-characterized adult white individuals participating in the CATAMERI study, who were reexamined after a mean follow-up of 5.6 ± 0.9 years. In our analysis we acquired a significant negative correlation between Mg2 levels, fasting glucose, and 2h-post load glucose in subjects who underwent an OGTT. Moreover, Mg2 levels correlated negatively with fasting insulin levels, and positively with the lipid profile. As for the detrimental effect of lower circulating Mg2 levels, our data revealed a significant reduction of T2DM risk of about 20% for each 1 mg/dL increase of circulating Mg2 . The present results are consistent with the theory that Mg2 supplementation could ameliorate insulin sensitivity reducing the risk to develop T2DM.
关键词：magnesium; type 2 diabetes; glucose tolerance; survival analysis magnesium ; type 2 diabetes ; glucose tolerance ; survival analysis