文章基本信息

标题：The Association between Alcohol Consumption and Serum Metabolites and the Modifying Effect of Smoking
本地全文：下载
作者：Julia Langenau ; Heiner Boeing ; Manuela M. Bergmann 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：10
页码：2331-2343
DOI：10.3390/nu11102331
出版社：MDPI Publishing
摘要：Alcohol consumption is an important lifestyle factor that is associated with several health conditions and a behavioral link with smoking is well established. Metabolic alterations after alcohol consumption have yet to be comprehensively investigated. We studied the association of alcohol consumption with metabolite patterns (MPs) among 2433 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study, and a potential modification by smoking. Alcohol consumption was self-reported through dietary questionnaires and serum metabolites were measured by a targeted approach. The metabolites were summarized as MPs using the treelet transform analysis (TT). We fitted linear models with alcohol consumption continuously and in five categories. We stratified the continuously modelled alcohol consumption by smoking status. All models were adjusted for potential confounders. Among men, alcohol consumption was positively associated with six MPs and negatively associated with one MP. In women, alcohol consumption was inversely associated with one MP. Heavy consumers differed from other consumers with respect to the “Long and short chain acylcarnitines” MP. Our findings suggest that long and short chain acylcarnitines might play an important role in the adverse effects of heavy alcohol consumption on chronic diseases. The relations seem to depend on gender and smoking status.
关键词：alcohol; smoking; targeted metabolomics; metabolite patterns; lipid metabolites; amino acids; acylcarnitines alcohol ; smoking ; targeted metabolomics ; metabolite patterns ; lipid metabolites ; amino acids ; acylcarnitines