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标题：The Paradox of Coenzyme Q10 in Aging
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作者：M. Elena Díaz-Casado ; José L. Quiles ; Eliana Barriocanal-Casado 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：9
页码：2221-2253
DOI：10.3390/nu11092221
出版社：MDPI Publishing
摘要：Coenzyme Q (CoQ) is an essential endogenously synthesized molecule that links different metabolic pathways to mitochondrial energy production thanks to its location in the mitochondrial inner membrane and its redox capacity, which also provide it with the capability to work as an antioxidant. Although defects in CoQ biosynthesis in human and mouse models cause CoQ deficiency syndrome, some animals models with particular defects in the CoQ biosynthetic pathway have shown an increase in life span, a fact that has been attributed to the concept of mitohormesis. Paradoxically, CoQ levels decline in some tissues in human and rodents during aging and coenzyme Q10 (CoQ10) supplementation has shown benefits as an anti-aging agent, especially under certain conditions associated with increased oxidative stress. Also, CoQ10 has shown therapeutic benefits in aging-related disorders, particularly in cardiovascular and metabolic diseases. Thus, we discuss the paradox of health benefits due to a defect in the CoQ biosynthetic pathway or exogenous supplementation of CoQ10.
关键词：mitohormesis; antioxidant; mitochondria; anti-aging; diet; aging-related diseases mitohormesis ; antioxidant ; mitochondria ; anti-aging ; diet ; aging-related diseases