文章基本信息

标题：Microbial Metabolites of Flavan-3-Ols and Their Biological Activity
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作者：Estefanía Márquez Campos ; Peter Stehle ; Marie-Christine Simon 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：10
页码：2260-2286
DOI：10.3390/nu11102260
出版社：MDPI Publishing
摘要：Flavan-3-ols are the main contributors to polyphenol intake. Many varying beneficial health effects in humans have been attributed to them, including the prevention of cardiovascular disease and cancer. Nevertheless, the mechanisms by which these flavonoids could exert beneficial functions are not entirely known. Several in vitro studies and in vivo animal models have tried to elucidate the role of the specific colonic metabolites on the health properties that are attributed to the parent compounds since a larger number of ingested flavan-3-ols reach the colon and undergo there microbial metabolism. Many new studies about this topic have been performed over the last few years and, to the best of our knowledge, no scientific literature review regarding the bioactivity of all identified microbial metabolites of flavan-3-ols has been recently published. Therefore, the aim of this review is to present the current status of knowledge on the potential health benefits of flavan-3-ol microbial metabolites in humans while using the latest evidence on their biological activity.
关键词：polyphenols; flavonoids; microbiota; metabolism polyphenols ; flavonoids ; microbiota ; metabolism