文章基本信息

标题：The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility
本地全文：下载
作者：Roberta Fontana ; Sara Della Torre
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2016
卷号：8
期号：2
页码：87-120
DOI：10.3390/nu8020087
出版社：MDPI Publishing
摘要：In female mammals, mechanisms have been developed, throughout evolution, to integrate environmental, nutritional and hormonal cues in order to guarantee reproduction in favorable energetic conditions and to inhibit it in case of food scarcity. This metabolic strategy could be an advantage in nutritionally poor environments, but nowadays is affecting women’s health. The unlimited availability of nutrients, in association with reduced energy expenditure, leads to alterations in many metabolic pathways and to impairments in the finely tuned inter-relation between energy metabolism and reproduction, thereby affecting female fertility. Many energetic states could influence female reproductive health being under- and over-weight, obesity and strenuous physical activity are all conditions that alter the profiles of specific hormones, such as insulin and adipokines, thus impairing women fertility. Furthermore, specific classes of nutrients might affect female fertility by acting on particular signaling pathways. Dietary fatty acids, carbohydrates, proteins and food-associated components (such as endocrine disruptors) have per se physiological activities and their unbalanced intake, both in quantitative and qualitative terms, might impair metabolic homeostasis and fertility in premenopausal women. Even though we are far from identifying a “fertility diet”, lifestyle and dietary interventions might represent a promising and invaluable strategy to manage infertility in premenopausal women.
关键词：fertility; reproduction; women; energy metabolism; nutrients fertility ; reproduction ; women ; energy metabolism ; nutrients