文章基本信息

标题：Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice
本地全文：下载
作者：Jungbin Song ; Young-Sik Kim ; Linae Kim 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：9
页码：2176-2187
DOI：10.3390/nu11092176
出版社：MDPI Publishing
摘要：Prunus persica (L.) Batsch is a deciduous fruit tree cultivated worldwide. The flower of P. persica (PPF), commonly called the peach blossom, is currently consumed as a tea for weight loss in East Asia; however, its anti-obesity effects have yet to be demonstrated in vitro or in vivo. Since PPF is rich in phytochemicals with anti-obesity properties, we aimed to investigate the effects of PPF on obesity and its underlying mechanism using a diet-induced obesity model. Male C57BL/6 mice were fed either normal diet, high-fat diet (HFD), or HFD containing 0.2% or 0.6% PPF water extract for 8 weeks. PPF significantly reduced body weight, abdominal fat mass, serum glucose, alanine transaminase and aspartate aminotransferase levels, and liver and spleen weights compared to the HFD control group. Real-time quantitative polymerase chain reaction analysis revealed that PPF suppressed lipogenic gene expression, including stearoyl-CoA desaturase-1 and -2 and fatty acid synthase, and up-regulated the fatty acid β-oxidation gene, carnitine palmitoyltransferase-1, in the liver. Our results suggest that PPF exerts anti-obesity effects in obese mice and these beneficial effects might be mediated through improved hepatic lipid metabolism by reducing lipogenesis and increasing fatty acid oxidation.
关键词：Prunus persica ; peach blossom; high-fat diet; anti-obesity; glucose; liver; lipogenesis; β-oxidation Prunus persica ; peach blossom ; high-fat diet ; anti-obesity ; glucose ; liver ; lipogenesis ; β-oxidation