文章基本信息

标题：Sodium Intake and Hypertension
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作者：Andrea Grillo ; Lucia Salvi ; Paolo Coruzzi 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：9
页码：1970-1985
DOI：10.3390/nu11091970
出版社：MDPI Publishing
摘要：The close relationship between hypertension and dietary sodium intake is widely recognized and supported by several studies. A reduction in dietary sodium not only decreases the blood pressure and the incidence of hypertension, but is also associated with a reduction in morbidity and mortality from cardiovascular diseases. Prolonged modest reduction in salt intake induces a relevant fall in blood pressure in both hypertensive and normotensive individuals, irrespective of sex and ethnic group, with larger falls in systolic blood pressure for larger reductions in dietary salt. The high sodium intake and the increase in blood pressure levels are related to water retention, increase in systemic peripheral resistance, alterations in the endothelial function, changes in the structure and function of large elastic arteries, modification in sympathetic activity, and in the autonomic neuronal modulation of the cardiovascular system. In this review, we have focused on the effects of sodium intake on vascular hemodynamics and their implication in the pathogenesis of hypertension.
关键词：arterial stiffness; endothelial function; hypertension; salt-sensitivity; salt intake; sodium intake; sympathetic activity arterial stiffness ; endothelial function ; hypertension ; salt-sensitivity ; salt intake ; sodium intake ; sympathetic activity