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标题：Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk
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作者：Ulla Uusitalo ; Carin Andren Aronsson ; Xiang Liu 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：8
页码：1790-1803
DOI：10.3390/nu11081790
出版社：MDPI Publishing
摘要：Probiotics are linked to positive regulatory effects on the immune system. The aim of the study was to examine the association between the exposure of probiotics via dietary supplements or via infant formula by the age of 1 year and the development of celiac disease autoimmunity (CDA) and celiac disease among a cohort of 6520 genetically susceptible children. Use of probiotics during the first year of life was reported by 1460 children. Time-to-event analysis was used to examine the associations. Overall exposure of probiotics during the first year of life was not associated with either CDA (n = 1212) (HR 1.15; 95%CI 0.99, 1.35; p = 0.07) or celiac disease (n = 455) (HR 1.11; 95%CI 0.86, 1.43; p = 0.43) when adjusting for known risk factors. Intake of probiotic dietary supplements, however, was associated with a slightly increased risk of CDA (HR 1.18; 95%CI 1.00, 1.40; p = 0.043) compared to children who did not get probiotics. It was concluded that the overall exposure of probiotics during the first year of life was not associated with CDA or celiac disease in children at genetic risk.
关键词：probiotics; dietary supplements; infant formula; celiac disease autoimmunity; celiac disease probiotics ; dietary supplements ; infant formula ; celiac disease autoimmunity ; celiac disease