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标题：The Relevance of Toxic AGEs (TAGE) Cytotoxicity to NASH Pathogenesis: A Mini-Review
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作者：Akiko Sakasai-Sakai ; Takanobu Takata ; Jun-ichi Takino 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：2
页码：462-469
DOI：10.3390/nu11020462
出版社：MDPI Publishing
摘要：Non-alcoholic fatty liver disease (NAFLD) is currently the most common feature of chronic liver disease. Non-alcoholic steatohepatitis (NASH) is a severe form of NAFLD, and one of its risk factors is hyperglycemia. The chronic ingestion of excessive amounts of high-fructose corn syrup is associated with an increased prevalence of fatty liver. Under hyperglycemic conditions, advanced glycation end-products (AGEs) are generated through a non-enzymatic glycation reaction between the ketone or aldehyde groups of sugars and amino groups of proteins. Glyceraldehyde (GA) is a metabolic intermediate of sugars, and GA-derived AGEs (known as toxic AGEs (TAGE)) have been implicated in the development of NASH. TAGE accumulates more in serum or liver tissue in NASH patients than in healthy controls or patients with simple steatosis. Furthermore, the TAGE precursor, GA, causes cell damage through protein dysfunctions by TAGE modifications and induces necrotic-type hepatocyte death. Intracellular TAGE may leak outside of necrotic-type cells. Extracellular TAGE then induce inflammatory or fibrotic responses related to the pathology of NASH in surrounding cells, including hepatocytes and hepatic stellate cells. This review focuses on the contribution of TAGE to the pathology of NASH, particularly hepatic cell death related to NASH.
关键词：non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH); advanced glycation end-products (AGEs); glyceraldehyde (GA); glyceraldehyde-derived AGEs; toxic AGEs (TAGE); hepatocytes; hepatocyte stellate cell (HSCs) non-alcoholic fatty liver disease (NAFLD) ; non-alcoholic steatohepatitis (NASH) ; advanced glycation end-products (AGEs) ; glyceraldehyde (GA) ; glyceraldehyde-derived AGEs ; toxic AGEs (TAGE) ; hepatocytes ; hepatocyte stellate cell (HSCs)