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标题：In Search of Panacea—Review of Recent Studies Concerning Nature-Derived Anticancer Agents
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作者：Dawid Przystupski ; Magdalena J. Niemczura ; Agata Górska 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：6
页码：1426-1463
DOI：10.3390/nu11061426
出版社：MDPI Publishing
摘要：Cancers are one of the leading causes of deaths affecting millions of people around the world, therefore they are currently a major public health problem. The treatment of cancer is based on surgical resection, radiotherapy, chemotherapy or immunotherapy, much of which is often insufficient and cause serious, burdensome and undesirable side effects. For many years, assorted secondary metabolites derived from plants have been used as antitumor agents. Recently, researchers have discovered a large number of new natural substances which can effectively interfere with cancer cells’ metabolism. The most famous groups of these compounds are topoisomerase and mitotic inhibitors. The aim of the latest research is to characterize natural compounds found in many common foods, especially by means of their abilities to regulate cell cycle, growth and differentiation, as well as epigenetic modulation. In this paper, we focus on a review of recent discoveries regarding nature-derived anticancer agents.
关键词：natural substances; nutraceuticals; phytochemicals; chemoprevention; nutri-epigenetics; anticancer research; mitotic inhibitors; topoisomerase inhibitors; xenobiotics; 6-gingerol; honokiol; polyphenols; drug resistance natural substances ; nutraceuticals ; phytochemicals ; chemoprevention ; nutri-epigenetics ; anticancer research ; mitotic inhibitors ; topoisomerase inhibitors ; xenobiotics ; 6-gingerol ; honokiol ; polyphenols ; drug resistance