文章基本信息

标题：Impact of Gut Microbiota Composition on Onset and Progression of Chronic Non-Communicable Diseases
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作者：Annalisa Noce ; Giulia Marrone ; Francesca Di Daniele 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：5
页码：1073-1107
DOI：10.3390/nu11051073
出版社：MDPI Publishing
摘要：In recent years, mounting scientific evidence has emerged regarding the evaluation of the putative correlation between the gut microbiota composition and the presence of chronic non-communicable diseases (NCDs), such as diabetes mellitus, chronic kidney disease, and arterial hypertension. The aim of this narrative review is to examine the current literature with respect to the relationship between intestinal dysbiosis and the insurgence/progression of chronic NCDs, analyzing the physiopathological mechanisms that can induce microbiota modification in the course of these pathologies, and the possible effect induced by microbiota alteration upon disease onset. Therapy based on probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplant can represent a useful therapeutic tool, as has been highlighted on animal studies. To this moment, clinical studies that intended to demonstrate the beneficial effect induced by this kind of oral supplementation on the gut microbiota composition, and subsequent amelioration of signs and symptoms of chronic NCDs have been conducted on limited sample populations for a limited follow-up period. Therefore, to fully evaluate the therapeutic value of this kind of intervention, it would be ideal to design ample population; randomized clinical trials with a lengthy follow up period.
关键词：chronic non-communicable diseases; gut microbiota; prebiotics; probiotics; synbiotics; dysbiosis chronic non-communicable diseases ; gut microbiota ; prebiotics ; probiotics ; synbiotics ; dysbiosis