文章基本信息

标题：Natural Products and Acute Myeloid Leukemia: A Review Highlighting Mechanisms of Action
本地全文：下载
作者：Dongwon Hwang ; Minsun Kim ; Hyejin Park 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：5
页码：1010-1031
DOI：10.3390/nu11051010
出版社：MDPI Publishing
摘要：Recent findings have shown great potential of alternative interventions such as immunotherapy and natural products for acute myeloid leukemia (AML). This study aims to review the anti-AML effect of various natural compounds. Natural compounds were classified into five groups: alkaloids, carotenoids, nitrogen-containing compounds, organosulfur compounds or phenolics based on each compound’s chemical properties. Fifty-eight studies were collected and reviewed in this article. Phenolics are the most abundant group to have an apoptotic effect over AML cells, while other groups have also shown significant apoptotic effects. Some compounds induced apoptosis by regulating unique mechanism like human telomerase reverse transcriptase (hTERT) or laminin receptor (67LR), while others modified caspases, poly (adp-ribose) polymerase (PARP) and p53. Further study is required to identify side-effects of potent compounds and the synergistic effects of combination of two or more natural compounds or existing conventional anti-AML drugs to treat this dreadful disease.
关键词：acute myeloid leukemia; natural products; alkaloids; carotenoids; nitrogen-containing compounds; organosulfur compounds; phenolics; apoptosis acute myeloid leukemia ; natural products ; alkaloids ; carotenoids ; nitrogen-containing compounds ; organosulfur compounds ; phenolics ; apoptosis