文章基本信息

标题：Lisosan G Protects the Retina from Neurovascular Damage in Experimental Diabetic Retinopathy
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作者：Rosario Amato ; Maria Grazia Rossino ; Maurizio Cammalleri 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2018
卷号：10
期号：12
页码：1932-1950
DOI：10.3390/nu10121932
出版社：MDPI Publishing
摘要：Lisosan G (LG), a fermented powder obtained from whole grains, is a recognized antioxidant compound that improves the bioactivity and survival of different cell types. The purpose of this study was to investigate whether LG ameliorates both the neural and the vascular damage characterizing early stages of diabetic retinopathy (DR). The effects of LG were studied in cultured explants of mouse retinas challenged with oxidative stress (OS) or in retinas of streptozotocin (STZ)-treated rats. Apoptosis, vascular endothelial growth factor (VEGF) expression, OS markers, blood-retinal barrier (BRB) integrity, and inflammation were assessed, while retinal function was evaluated with electroretinogram (ERG). LG extensively inhibited apoptosis, VEGF expression, and OS both in retinal explants and in STZ rats. In addition, STZ rats treated with LG displayed an almost total BRB integrity, reduced levels of inflammatory markers and a partially restored visual function as evaluated with ERG. In summary, we demonstrated that LG exhibits antioxidant and anti-inflammatory effects that exert powerful protective actions against neural and vascular defects characteristic of DR. Therefore, LG-containing foods or supplements may be considered to implement DR treatments.
关键词：neuroprotection; nutraceuticals; oxidative stress; retinal explant; streptozotocin; VEGF neuroprotection ; nutraceuticals ; oxidative stress ; retinal explant ; streptozotocin ; VEGF