文章基本信息

标题：The Role of Autophagy in Liver Epithelial Cells and Its Impact on Systemic Homeostasis
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作者：Luana Tomaipitinca ; Sara Mandatori ; Romina Mancinelli 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：4
页码：827-845
DOI：10.3390/nu11040827
出版社：MDPI Publishing
摘要：Autophagy plays a role in several physiological and pathological processes as it controls the turnover rate of cellular components and influences cellular homeostasis. The liver plays a central role in controlling organisms’ metabolism, regulating glucose storage, plasma proteins and bile synthesis and the removal of toxic substances. Liver functions are particularly sensitive to autophagy modulation. In this review we summarize studies investigating how autophagy influences the hepatic metabolism, focusing on fat accumulation and lipids turnover. We also describe how autophagy affects bile production and the scavenger function within the complex homeostasis of the liver. We underline the role of hepatic autophagy in counteracting the metabolic syndrome and the associated cardiovascular risk. Finally, we highlight recent reports demonstrating how the autophagy occurring within the liver may affect skeletal muscle homeostasis as well as different extrahepatic solid tumors, such as melanoma.
关键词：autophagy; liver; lipid droplets; metabolism; oxidative stress; cancer autophagy ; liver ; lipid droplets ; metabolism ; oxidative stress ; cancer