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标题：Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults
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作者：Andrew W. McHill ; Charles A. Czeisler ; Andrew J. K. Phillips 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：3
页码：587-599
DOI：10.3390/nu11030587
出版社：MDPI Publishing
摘要：The timing of caloric intake is a risk factor for excess weight and disease. Growing evidence suggests, however, that the impact of caloric consumption on metabolic health depends on its circadian phase, not clock hour. The objective of the current study was to identify how individuals consume calories and macronutrients relative to circadian phase in real-world settings. Young adults (n = 106; aged 19 ± 1 years; 45 females) photographically recorded the timing and content of all calories for seven consecutive days using a smartphone application during a 30-day study. Circadian phase was determined from in-laboratory assessment of dim-light melatonin onset (DLMO). Meals were assigned a circadian phase relative to each participant’s DLMO (0°, ~23:17 h) and binned into 60° bins. Lean (n = 68; 15 females) and non-lean (n = 38, 30 females) body composition was determined via bioelectrical impedance. The DLMO time range was ~10 h, allowing separation of clock time and circadian phase. Eating occurred at all circadian phases, with significant circadian rhythmicity (p 0.05). Interventions targeting the circadian timing of calories and macronutrients for weight management should be tested.
关键词：metabolism; sleep duration; body composition; caloric intake; melatonin metabolism ; sleep duration ; body composition ; caloric intake ; melatonin