文章基本信息

标题：Glycomacropeptide Bioactivity and Health: A Review Highlighting Action Mechanisms and Signaling Pathways
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作者：Laura Elena Córdova-Dávalos ; Mariela Jiménez ; Eva Salinas 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：3
页码：598-619
DOI：10.3390/nu11030598
出版社：MDPI Publishing
摘要：Food-derived bioactive peptides are reported as beneficial and safe for human health. Glycomacropeptide (GMP) is a milk-protein-derived peptide that, in addition to its nutritional value, retains many biological properties and has therapeutic effects in several inflammatory disorders. GMP was shown under in vitro and in vivo conditions to exert a number of activities that regulate the physiology of important body systems, namely the gastrointestinal, endocrine, and immune systems. This review represents a comprehensive compilation summarizing the current knowledge and updated information on the major biological properties associated with GMP. GMP bioactivity is addressed with special attention on mechanisms of action, signaling pathways involved, and structural characteristics implicated. In addition, the results of various studies dealing with the effects of GMP on models of inflammatory diseases are reviewed and discussed.
关键词：glycomacropeptide; milk-derived bioactive peptide; antibacterial; prebiotic; remineralizing; metabolism; anti-tumoral; immuno-modulatory; action mechanisms glycomacropeptide ; milk-derived bioactive peptide ; antibacterial ; prebiotic ; remineralizing ; metabolism ; anti-tumoral ; immuno-modulatory ; action mechanisms