文章基本信息

标题：Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis
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作者：Eduardo Dourado ; Margarida Ferro ; Catarina Sousa Guerreiro 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：11
页码：3504-3522
DOI：10.3390/nu12113504
出版社：MDPI Publishing
摘要：Rheumatoid arthritis (RA) is a chronic immune-driven inflammatory disease characterised by synovial inflammation, leading to progressive cartilage and bone destruction, impacting patients’ functional capacity and quality of life. Patients with RA have significant differences in gut microbiota composition when compared to controls. Intestinal dysbiosis influences the intestinal barrier strength, integrity and function, and diet is considered the main environmental factor impacting gut microbiota. Over the last few years, researchers have focused on the influence of single components of the diet in the modulation of intestinal microbiota in RA rather than whole dietary patterns. In this review, we focus on how the Mediterranean diet (MD), a whole dietary pattern, could possibly act as an adjuvant therapeutic approach, modulating intestinal microbiota and intestinal barrier function in order to improve RA-related outcomes. We also review the potential effects of particular components of the MD, such as n-3 polyunsaturated fatty acids (PUFAs), polyphenols and fibre.
关键词：rheumatoid arthritis; gut microbiota; Mediterranean diet; probiotics rheumatoid arthritis ; gut microbiota ; Mediterranean diet ; probiotics