文章基本信息

标题：The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study
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作者：Emilia Vassilopoulou ; George N. Konstantinou ; Anastasia Dimitriou 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：11
页码：3402-3415
DOI：10.3390/nu12113402
出版社：MDPI Publishing
摘要：Asthma is a complex chronic inflammatory disorder. Diet’s impact on asthma symptoms is controversial. The objective of this pilot crossover, randomized, two-period study was to examine the effect of dietary histamine intake on asthma symptoms in twenty-one children with mild intermittent asthma. Children were randomly assigned to either a high- or low-histamine diet, based on the Mediterranean pattern, for 4 weeks. After a 2-week washout period, patients crossed to the alternative diet for 4 additional weeks. Asthma symptoms were assessed at baseline and after the completion of each diet period by a clinician. Daily symptoms and peak flow were recorded throughout the intervention. Adherence to the dietary intervention was assessed via analysis of four random 24-h recalls, for each intervention period. Eighteen children completed the study. Significantly higher mean air flow obstruction was recorded and a trend for prolonged and more severe symptoms was observed during the high-histamine period. Diet may have an active and direct impact on asthma symptoms. Food choice is affected and/or may affect symptoms in children with mild asthma. Diet intervention is promising yet challenging, for asthma control.
关键词：asthma; nutritional intervention; food histamine; Mediterranean diet; Western diet; antioxidants; anti-inflammatory diet asthma ; nutritional intervention ; food histamine ; Mediterranean diet ; Western diet ; antioxidants ; anti-inflammatory diet