文章基本信息

标题：ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizing Enzymes Involved
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作者：Maolin Tu ; Weicang Wang ; Guodong Zhang 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：11
页码：3301-3318
DOI：10.3390/nu12113301
出版社：MDPI Publishing
摘要：Substantial human and animal studies support the beneficial effects of ω-3 polyunsaturated fatty acids (PUFAs) on colonic inflammation and colorectal cancer (CRC). However, there are inconsistent results, which have shown that ω-3 PUFAs have no effect or even detrimental effects, making it difficult to effectively implement ω-3 PUFAs for disease prevention. A better understanding of the molecular mechanisms for the anti-inflammatory and anticancer effects of ω-3 PUFAs will help to clarify their potential health-promoting effects, provide a scientific base for cautions for their use, and establish dietary recommendations. In this review, we summarize recent studies of ω-3 PUFAs on colonic inflammation and CRC and discuss the potential roles of ω-3 PUFA-metabolizing enzymes, notably the cytochrome P450 monooxygenases, in mediating the actions of ω-3 PUFAs.
关键词：ω-3 PUFAs; colonic inflammation; colorectal cancer; eicosanoids; cytochrome P450 monooxygenases; soluble epoxide hydrolase ω-3 PUFAs ; colonic inflammation ; colorectal cancer ; eicosanoids ; cytochrome P450 monooxygenases ; soluble epoxide hydrolase