文章基本信息

标题：Vitamin K and Kidney Transplantation
本地全文：下载
作者：Maria Fusaro ; Laura Cosmai ; Pieter Evenepoel 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：9
页码：2717-2729
DOI：10.3390/nu12092717
出版社：MDPI Publishing
摘要：The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches.
关键词：kidney; transplant; phylloquinone; menaquinone; vitamin K; osteoporosis; bone; fracture; cardiovascular disease; calcification; cancer kidney ; transplant ; phylloquinone ; menaquinone ; vitamin K ; osteoporosis ; bone ; fracture ; cardiovascular disease ; calcification ; cancer