文章基本信息

标题：Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa
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作者：Kamil Skowron ; Magdalena Kurnik-Łucka ; Emil Dadański 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：9
页码：2604-2635
DOI：10.3390/nu12092604
出版社：MDPI Publishing
摘要：Anorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological aspects involving central and peripheral neurohormonal pathways, endocrine function, as well as the microbiome–gut–brain axis. It emerged from the unique complexity of constantly accumulating new discoveries, which hamper the ability to look at the disease in a more comprehensive way. The emphasis is placed on the mechanisms underlying the main symptoms and potential new directions that require further investigation in clinical settings.
关键词：anorexia nervosa; eating disorders; starvation; hyperactivity; neuropeptides; microbiome–gut–brain axis anorexia nervosa ; eating disorders ; starvation ; hyperactivity ; neuropeptides ; microbiome–gut–brain axis