文章基本信息

标题：Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews
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作者：Muhammad Daniel Hakim Mohd Jamil ; Muhammad Taher ; Deny Susanti 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：9
页码：2584-2599
DOI：10.3390/nu12092584
出版社：MDPI Publishing
摘要：Picrasma quassioides is a member of the Simaroubaceae family commonly grown in the regions of Asia, the Himalayas, and India and has been used as a traditional herbal medicine to treat various illnesses such as fever, gastric discomfort, and pediculosis. This study aims to critically review the presence of phytochemicals in P. quassioides and correlate their pharmacological activities with the significance of its use as traditional medicine. Data were collected by reviewing numerous scientific articles from several journal databases on the pharmacological activities of P. quassioides using certain keywords. As a result, approximately 94 phytochemicals extracted from P. quassioides were found to be associated with quassinoids, β-carbolines and canthinones. These molecules exhibited various pharmacological benefits such as anti-inflammatory, antioxidant, anti-cancer, anti-microbial, and anti-parasitic activities which help to treat different diseases. However, P. quassioides were also found to have several toxicity effects in high doses, although the evidence regarding these effects is limited in proving its safe use and efficacy as herbal medicine. Accordingly, while it can be concluded that P. quassioides may have many potential pharmacological benefits with more phytochemistry discoveries, further research is required to determine its real value in terms of quality, safety, and efficacy of use.
关键词：Picrasma quassioides ; Simaroubaceae ; anti-inflammatory; antioxidant; anti-malarial; antifeedant; anti-cancer; anti-ulcer; quassinoids Picrasma quassioides ; Simaroubaceae ; anti-inflammatory ; antioxidant ; anti-malarial ; antifeedant ; anti-cancer ; anti-ulcer ; quassinoids