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标题：Quantification of Human Milk Phospholipids: the Effect of Gestational and Lactational Age on Phospholipid Composition
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作者：Ida Emilie Ingvordsen Lindahl ; Virginia M. Artegoitia ; Eimear Downey 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：2
页码：222-235
DOI：10.3390/nu11020222
出版社：MDPI Publishing
摘要：Human milk (HM) provides infants with macro- and micronutrients needed for growth and development. Milk phospholipids are important sources of bioactive components, such as long-chain polyunsaturated fatty acids (LC-PUFA) and choline, crucial for neural and visual development. Milk from mothers who have delivered prematurely (2 weeks and ≤15 weeks) samples from mothers who had delivered preterm (n = 57) and term infants (n = 22), respectively. Both gestational age and age postpartum affected the PL composition of HM. Significantly higher concentrations (p < 0.05) of phosphatidylcholine (PC), sphingomyelin (SM) and total PL were found in preterm milk throughout lactation, as well as significantly higher concentrations (p < 0.002) of several phosphatidylethanolamine (PE), PC and SM species. Multivariate analysis revealed that PLs containing LC-PUFA contributed highly to the differences in the PL composition of preterm and term colostrum. Differences related to gestation decreased as the milk matured. Thus, gestational age may impact the PL content of colostrum, however this effect of gestation might subside in mature milk.
关键词：Human Milk; Preterm infant; Phospholipids; Lipidomics; Milk Fat Globule Membrane Human Milk ; Preterm infant ; Phospholipids ; Lipidomics ; Milk Fat Globule Membrane