文章基本信息

标题：β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model
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作者：Silvia Llopis ; María Jesús Rodrigo ; Nuria González 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：2
页码：232-251
DOI：10.3390/nu11020232
出版社：MDPI Publishing
摘要：β-Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investigated. The Caenorhabditis elegans model was used to analyze in vivo the activity of BCX on fat reduction and protection to oxidative stress. Dose-response assays provided evidence of the efficacy of BCX at very low dose (0.025 µg/mL) (p < 0.001) on these processes. Moreover, a comparative analysis with other carotenoids, such as lycopene and β-carotene, showed a stronger effect of BCX. Furthermore, a transcriptomic analysis of wild-type nematodes supplemented with BCX revealed upregulation of the energy metabolism, response to stress, and protein homeostasis as the main metabolic targets of this xanthophyll. Collectively, this study provides new in vivo evidence of the potential therapeutic use of BCX in the prevention of diseases related to metabolic syndrome and aging.
关键词：β-Cryptoxanthin; carotenoids; Caenorhabditis elegans ; fat reduction; oxidative stress; transcriptomic analysis; metabolic syndrome; aging β-Cryptoxanthin ; carotenoids ; Caenorhabditis elegans ; fat reduction ; oxidative stress ; transcriptomic analysis ; metabolic syndrome ; aging