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标题：Effect of Probiotics on Oral Candidiasis: A Systematic Review and Meta-Analysis
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作者：Tiziana Mundula ; Federica Ricci ; Beatrice Barbetta 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2019
卷号：11
期号：10
页码：2449-2467
DOI：10.3390/nu11102449
出版社：MDPI Publishing
摘要：Oral candidiasis (OC) is an increasing health problem due to the introduction of new drugs, population aging, and increasing prevalence of chronic illness. This study systematically reviews the effects of the oral intake of probiotics, prebiotics, and synbiotics on Candida spp. counts (colony-forming units (CFU)/mL) in oral and palatal samples. A literature search was conducted. Twelve studies, eight randomized clinical trials (RCTs), and four pre-post studies, resulted as eligible for the meta-analysis, which was performed through a Bayesian random-effects model. All studies analyzed probiotics, and none of them analyzed prebiotics or synbiotics. The treatments effects were measured in terms of odds ratio (OR) of OC (CFU/mL >102, 103, or 104). The meta-analytic OR was 0.71 (95% credibility interval (CrI): 0.37, 1.32), indicating a beneficial effect of treatment; the I2 index was 56.3%. Focusing only on RCTs, the OR was larger and more precise at 0.53 (95% CrI: 0.27, 0.93). The effect of treatment appeared to be larger on denture wearers. Our findings indicate that the intake of probiotics can have a beneficial effect on OC and that the effects could vary according to the patients’ characteristics. Due to the presence of medium–high-risk studies, the results should be interpreted with caution.
关键词：Candida spp;; oral candidiasis; Candida spp; treatment; Candida spp; prevention; Candida spp; carriage; probiotics; microbiota; Bayesian meta-analysis Candida spp; ; oral candidiasis ; Candida spp; treatment ; Candida spp; prevention ; Candida spp; carriage ; probiotics ; microbiota ; Bayesian meta-analysis