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标题：Supplementation with Fermented Rice Bran Attenuates Muscle Atrophy in a Diabetic Rat Model
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作者：Tubagus Bahtiar Rusbana ; Afifah Zahra Agista ; Wahyu Dwi Saputra 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：8
页码：2409-2422
DOI：10.3390/nu12082409
出版社：MDPI Publishing
摘要：Fermented rice bran (FRB), a prospective supplement, has been proven to ameliorate certain medical conditions. However, its nutraceutical effect on muscle atrophy has never been investigated. The present study aimed to evaluate the effect of FRB on muscle atrophy in a streptozotocin (STZ)-induced diabetic rat model. Three groups of Sprague-Dawley rats, namely the control, STZ, and FRB groups, were treated as follows. The diabetic groups (STZ and FRB) were injected intraperitoneally with STZ (40 mg/kg BW), whereas the control group was injected with the vehicle. The STZ and control groups were fed the AIN93M diet, and the FRB group was fed 10% of FRB based on the AIN93M diet. The diabetic groups had reduced muscle size compared to the control group; however, these changes were alleviated in the FRB group. Moreover, the FRB group had a significantly lower expression of FBXO32/Atrogin-1 and TRIM63/MuRF1 (p < 0.05) due to blocked NF-κB activation. In conclusion, the anti-inflammatory effect of FRB may be beneficial for ameliorating muscle atrophy in diabetic conditions.
关键词：fermented rice bran; muscle atrophy; diabetes mellitus; streptozotocin; FBXO32/Atrogin-1; TRIM63/MuRF1; NF-κB; anti-inflammation fermented rice bran ; muscle atrophy ; diabetes mellitus ; streptozotocin ; FBXO32/Atrogin-1 ; TRIM63/MuRF1 ; NF-κB ; anti-inflammation