文章基本信息

标题：The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases
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作者：Natalia Arias ; Silvia Arboleya ; Joseph Allison 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：8
页码：2340-2368
DOI：10.3390/nu12082340
出版社：MDPI Publishing
摘要：Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which, upon absorption by the host is converted into trimethylamine-N-oxide (TMAO) in the liver. A high accumulation of both components is related to cardiovascular disease, inflammatory bowel disease, non-alcoholic fatty liver disease, and chronic kidney disease. However, the relationship between the microbiota production of these components and its impact on these diseases still remains unknown. In this review, we will address which microbes contribute to TMA production in the human gut, the extent to which host factors (e.g., the genotype) and diet affect TMA production, and the colonization of these microbes and the reversal of dysbiosis as a therapy for these diseases.
关键词：choline; TMA; TMAO; non-alcoholic steatohepatitis (NASH); cardiovascular disease (CVD); chronic kidney diseases (CKD); probiotics; gut microbiota; polyphenols; fecal microbiota transplantation choline ; TMA ; TMAO ; non-alcoholic steatohepatitis (NASH) ; cardiovascular disease (CVD) ; chronic kidney diseases (CKD) ; probiotics ; gut microbiota ; polyphenols ; fecal microbiota transplantation