文章基本信息

标题：Probiotic Supplementation during the Perinatal and Infant Period: Effects on gut Dysbiosis and Disease
本地全文：下载
作者：Elisabet Navarro-Tapia ; Giorgia Sebastiani ; Sebastian Sailer 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：8
页码：2243-2292
DOI：10.3390/nu12082243
出版社：MDPI Publishing
摘要：The perinatal period is crucial to the establishment of lifelong gut microbiota. The abundance and composition of microbiota can be altered by several factors such as preterm delivery, formula feeding, infections, antibiotic treatment, and lifestyle during pregnancy. Gut dysbiosis affects the development of innate and adaptive immune responses and resistance to pathogens, promoting atopic diseases, food sensitization, and infections such as necrotizing enterocolitis (NEC). Recent studies have indicated that the gut microbiota imbalance can be restored after a single or multi-strain probiotic supplementation, especially mixtures of Lactobacillus and Bifidobacterium strains. Following the systematic search methodology, the current review addresses the importance of probiotics as a preventive or therapeutic tool for dysbiosis produced during the perinatal and infant period. We also discuss the safety of the use of probiotics in pregnant women, preterm neonates, or infants for the treatment of atopic diseases and infections.
关键词：probiotics; gut microbiota; dysbiosis; antibiotic resistance; autoimmune diseases; atopic diseases; necrotizing enterocolitis; pregnancy; fetal microbiota; preterm microbiota; infant microbiota; probiotic safety probiotics ; gut microbiota ; dysbiosis ; antibiotic resistance ; autoimmune diseases ; atopic diseases ; necrotizing enterocolitis ; pregnancy ; fetal microbiota ; preterm microbiota ; infant microbiota ; probiotic safety